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Related Experiment Video

Updated: Feb 18, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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OPTICAL COHERENCE TOMOGRAPHY 2: Diagnostic Tool to Study Peripheral Vitreoretinal Pathologies.

Matteo G Cereda1, Federico Corvi, Mariano Cozzi

  • 1Department of Biomedical and Clinical Science "Luigi Sacco," Eye Clinic, Sacco Hospital, University of Milan, Milan, Italy.

Retina (Philadelphia, Pa.)
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Summary

A new wide-field optical coherence tomography (OCT) device, OCT2, shows significant benefits for imaging peripheral retinal disorders. This technology improves the understanding and management of conditions affecting the mid and far retinal periphery.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Standard optical coherence tomography (OCT) has limitations in visualizing the peripheral retina.
  • Peripheral retinal disorders require accurate imaging for diagnosis and management.

Purpose of the Study:

  • To evaluate a new wide-field optical coherence tomography (OCT) device for imaging the mid and far retinal periphery.
  • To assess the clinical feasibility and advantages of this novel OCT technology.

Main Methods:

  • Consecutive patients underwent ophthalmologic examinations.
  • Standard OCT and a new prototype OCT2 device were utilized.
  • Lesion characterization included retinal detachments, holes, tears, and retinoschisis.

Main Results:

  • 44 peripheral retinal lesions were analyzed in 31 patients.
  • A majority of lesions (68%) were located in the far periphery.
  • The new OCT2 device imaged more lesions in both the mid (71%) and far (37%) periphery compared to standard OCT.

Conclusions:

  • The OCT2 device offers significant advantages for imaging peripheral retinal disorders.
  • This technology enhances the understanding and facilitates the management of peripheral vitreoretinal conditions.
  • Application of OCT2 with specific lens and scan modulations is promising.