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Published on: June 24, 2018
In vitro model of potential metal cation exchanges in biological apatite
Haishan Shi1, Jing Zhang2, Xiaoling Ye3
1National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 382 Zhonghuan Road East, Panyu District, Guangzhou 510006, People's Republic of China; School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Tianhe District, Guangzhou 510640, People's Republic of China; and College of Chemistry and Materials Science, Jinan University, 601 West Huangpu Avenue, Tianhe District, Guangzhou 510632, People's Republic of China.
Abstract:
Biological apatite is ion-doped and provides an active pool for the exchange with foreign impurity ions. In this work, an in vitro model of hydrated metastable octacalcium phosphate (OCP) crystals was established to mimetically investigate the distinct exchange of trivalent and divalent cations (Fe3+ and Sr2+) with biological apatite. Fe3+ significantly promoted the collapses of OCP crystals and the formation of amorphous sol-like ferric phosphates, while Sr2+ facilitated the epitaxial growth and stability of OCP crystals. The involvement of Ca2+ maintained the crystalline integrity and inhibited the ion exchange within OCP crystals. This in vitro model would lay the foundation for the further investigation of the metabolism of biological apatite.
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