Secondary Tumors After Urinary Diversion.
Roger Li1, Janet E Baack Kukreja1, Ashish M Kamat1
1Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373, Houston, TX 77030, USA.
The Urologic Clinics of North America
|November 25, 2017
Summary
Urinary diversions connecting the urinary and intestinal tracts increase secondary cancer risk. This review examines these unique tumors, their progression, and potential causes, offering insights into urinary and intestinal tract cancers.
Area of Science:
- Oncology
- Urology
- Gastroenterology
Background:
- Urinary diversions that connect the urinary and intestinal tracts are associated with a higher incidence of secondary malignancies.
- Tumorigenesis in ureterosigmoidostomies typically progresses from adenomas to adenocarcinomas.
- Secondary malignancies in isolated intestinal diversions exhibit more heterogeneous characteristics.
Purpose of the Study:
- To review the current understanding of secondary malignancies arising from urinary diversions.
- To summarize patterns of incidence and progression observed in these tumors over the past 50 years.
- To explore potential mechanisms driving neoplastic changes in urinary and intestinal tracts.
Main Methods:
- Literature review of research over the last half century.
- Analysis of incidence and progression patterns of secondary malignancies.
- Investigation of potential etiologies and mechanisms of tumorigenesis.
Main Results:
- Established link between urinary diversions and increased secondary cancer incidence.
- Characterization of distinct tumor progression pathways (ureterosigmoidostomies vs. isolated diversions).
- Identification of potential mechanisms contributing to neoplastic development.
Conclusions:
- Secondary malignancies following urinary diversion require further investigation.
- Understanding these unique tumors may elucidate etiologies of other urinary and intestinal cancers.
- Continued research is crucial for improving patient outcomes and cancer prevention strategies.
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