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Biomarkers to Predict Cardiovascular Death

Devinder S Dhindsa1, Jay Khambhati1, Pratik B Sandesara1

  • 1Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Road Northeast, Suite 507, Atlanta, GA 30322, USA.

Cardiac Electrophysiology Clinics
|November 28, 2017
PubMed

Insights

Biomarkers help identify individuals at high risk for cardiovascular death, especially those with heart disease. A multimarker approach combined with clinical factors improves risk assessment for sudden cardiac death.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Risk Stratification

Background:

  • Cardiovascular diseases remain a leading cause of mortality worldwide.
  • Accurate identification of individuals at high risk for cardiovascular death is crucial for timely intervention.
  • Biomarkers offer potential for improved risk assessment beyond traditional clinical factors.

Purpose of the Study:

  • To review current biomarkers for identifying individuals at increased risk of cardiovascular death.
  • To evaluate the evolving role of biomarkers in risk stratification for sudden cardiac death.
  • To assess the utility of multimarker strategies in different patient populations.

Main Methods:

  • Systematic review of published literature on cardiovascular biomarkers and risk prediction.
  • Analysis of studies focusing on general population, coronary artery disease (CAD), and heart failure cohorts.
  • Evaluation of multimarker strategies incorporating circulating proteins and clinical risk factors.

Main Results:

  • Biomarkers have demonstrated efficacy in identifying elevated cardiovascular death risk across diverse populations.
  • A multimarker strategy, combining protein measures and clinical factors, shows promise for near-term risk prediction in established CAD.
  • The cost-effectiveness of applying similar multimarker strategies to the general population requires further investigation.

Conclusions:

  • Biomarker-based risk stratification is a valuable tool in cardiovascular medicine.
  • Multimarker approaches, particularly in patients with coronary artery disease, enhance the identification of individuals at high risk for mortality.
  • Further research is needed to determine the clinical and economic benefits of widespread biomarker use for cardiovascular risk assessment in the general population.

Keywords:
BiomarkersCardiovascular deathRisk scoreRisk stratification

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