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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Related Experiment Video

Updated: Feb 18, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Probiotics in Inflammatory Bowel Disease.

Bincy P Abraham1, Eamonn M M Quigley2

  • 1Fondren Inflammatory Bowel Disease Program, Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Weill Cornell Medical College, 6550 Fannin Street, SM 1201, Houston, TX 77030, USA; Lynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital, Weill Cornell Medical College, 6550 Fannin Street, SM 1201, Houston, TX 77030, USA.

Gastroenterology Clinics of North America
|November 28, 2017
PubMed
Summary

Probiotics show promise for inflammatory bowel disease (IBD), particularly ulcerative colitis and pouchitis. However, current evidence suggests limited benefits for Crohn disease, prompting research into targeted microbial therapies.

Keywords:
Crohn diseaseInflammationInflammatory bowel diseaseMicrobiomeMicrobiotaPouchitisProbioticUlcerative colitis

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Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • The gut microbiota plays a crucial role in inflammatory bowel disease (IBD) pathogenesis.
  • Microbiota-host immune interactions are central to IBD development.
  • Targeting the gut microbiota is a promising therapeutic strategy for IBD.

Purpose of the Study:

  • To evaluate the efficacy of probiotics as a therapeutic strategy for IBD.
  • To review the evidence for probiotic use in different forms of IBD.
  • To explore novel, targeted microbial approaches for IBD treatment.

Main Methods:

  • Review of existing data from animal models of IBD.
  • Analysis of clinical evidence for probiotic efficacy in ulcerative colitis, pouchitis, and Crohn disease.
  • Evaluation of emerging targeted bacterial therapies.

Main Results:

  • Probiotics have demonstrated potential in animal models of IBD.
  • Some evidence supports probiotic efficacy in ulcerative colitis and pouchitis.
  • Limited evidence indicates probiotic benefit for Crohn disease.

Conclusions:

  • While probiotics show potential for certain IBD types, their efficacy in Crohn disease remains uncertain.
  • Targeted approaches using live bacteria, genetically modified bacteria, or bacterial products are under investigation for IBD.
  • Further research is needed to optimize microbiota-targeted therapies for IBD.