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The redesigned Forensic Research/Reference on Genetics-knowledge base, FROG-kb.

Kenneth K Kidd1, Usha Soundararajan1, Haseena Rajeevan2

  • 1Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

Forensic Science International. Genetics
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

The Forensic Resource/Reference on Genetics-knowledge base (FROG-kb) offers enhanced tools for forensic genetics. This redesigned database aids in analyzing single nucleotide polymorphisms (SNPs) for identification and ancestry inference.

Keywords:
Ancestry inferenceForensic resourceIndividual identificationKnowledge baseSNPsWeb site

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Area of Science:

  • Forensic Genetics
  • Bioinformatics
  • Population Genetics

Background:

  • The Forensic Resource/Reference on Genetics-knowledge base (FROG-kb) was established to support forensic applications of single nucleotide polymorphisms (SNPs).
  • Previous versions served as a prototype, highlighting the need for improved usability and functionality for forensic practitioners, educators, and researchers.

Purpose of the Study:

  • To present a comprehensive redesign of the FROG-kb website, enhancing its interface and functionality.
  • To introduce new reference panels and curated data for individual identification SNPs (IISNPs) and ancestry inference SNPs (AISNPs).
  • To provide updated tools for calculating random match probabilities (RMP) and likelihoods of ancestry based on user-provided genotype data.

Main Methods:

  • Redesign of the FROG-kb web interface for improved navigation and user experience.
  • Inclusion of new reference panels with curated data for IISNPs and AISNPs.
  • Development of algorithms to calculate RMP and relative likelihoods of ancestry from genotype profiles.

Main Results:

  • The redesigned FROG-kb offers enhanced navigation, functional improvements, and extensive new documentation.
  • New reference panels and curated data for IISNPs and AISNPs have been integrated.
  • The system provides calculations for RMP and ancestry likelihoods, with example profiles and interpretation guidelines.

Conclusions:

  • FROG-kb is a comprehensive, freely accessible tool facilitating the use of SNPs in forensic practice and education.
  • Ongoing updates and extensive documentation ensure its continued utility for genetic analysis in forensics.
  • The enhanced FROG-kb supports both individual identification and ancestry inference applications in forensic science.