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Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma
Shannon Kay1, Haseena Rajeevan2, Moeun Son3
1Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine.
Summary
Asthma
Area of Science:
- Immunology
- Genetics
- Respiratory Medicine
Background:
- Asthma exhibits sex-based differences in prevalence and severity throughout life.
- Females experience increased asthma symptoms post-puberty, despite decreased type 2 inflammation.
- Identifying sex-specific genetic factors in asthma is challenging due to genomic similarity.
Purpose of the Study:
- To investigate sex-biased gene expression in adult asthma.
- To correlate sex-biased gene expression with clinical asthma features.
- To explore age-specific gene expression patterns in pediatric asthma.
Main Methods:
- Meta-analysis of transcriptomes from blood samples of adult patients with and without asthma (n=3,639).
- Validation in a local cohort (n=132) to assess clinical correlations.
- Transcriptional meta-analysis for pediatric asthma.
Main Results:
- Identified 61 sex-differentially expressed genes in immune cells of adult asthma patients.
- These genes correlate with key clinical asthma features and are involved in immune responses.
- Age-specific gene expression effects were observed in pediatric asthma.
Conclusions:
- Asthma has a sex-specific inflammatory profile linked to differential gene expression in blood.
- These gene expression patterns are age-dependent.
- Findings highlight the importance of sex and age in asthma pathogenesis and management.
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