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Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese
Atsushi Hashimoto1, Shiori Suto1, Kouichiro Horie1
1Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan.
International Journal of Rheumatology
|November 29, 2017
Summary
Infections requiring hospitalization are common in rheumatoid arthritis (RA). Older age, male sex, lung disease, and certain medications like biologics increase the risk of pneumocystis pneumonia (PCP) in RA patients.
Area of Science:
- Rheumatology
- Infectious Diseases
- Epidemiology
Background:
- Rheumatoid arthritis (RA) patients face increased risks of various infections.
- Identifying specific risk factors for severe infections in RA is crucial for patient management.
Purpose of the Study:
- To determine the incidence of infections requiring hospitalization (IRH) in RA patients.
- To identify risk factors associated with IRH, including pneumocystis pneumonia (PCP), in RA.
Main Methods:
- Retrospective analysis of RA patients treated between 2009-2013.
- Multivariate logistic regression used to identify factors associated with IRH.
Main Results:
- 373 IRH cases occurred over 9210 patient-years; respiratory infections, including PCP, were most common.
- Risk factors for PCP included older age, male sex, lung disease, corticosteroids, and biologics.
- Methotrexate use was linked to increased PCP risk but decreased overall infection risk.
Conclusions:
- Specific risk factors for infections in RA patients have been identified.
- These findings should inform treatment decisions for individual RA patients to mitigate infection risk.
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