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Real-time endoscopic optical properties imaging.

Joseph P Angelo1,2, Martijn van de Giessen3, Sylvain Gioux4,5

  • 1Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Biomedical Optics Express
|December 1, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a new endoscopic imaging technique, 3D single snapshot of optical properties (3D-SSOP), for real-time surgical guidance. It accurately maps tissue optical properties and topography, aiding minimally invasive procedures.

Keywords:
(170.0110) Imaging systems(170.0170) Medical optics and biotechnology(170.2150) Endoscopic imaging

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Area of Science:

  • Medical Imaging
  • Optical Engineering
  • Surgical Technology

Background:

  • Minimally invasive surgery is increasingly common, necessitating advanced guidance tools.
  • Quantitative endoscopic imaging is crucial for real-time surgical decision-making.
  • Widefield optical imaging offers potential for endoscopic applications.

Purpose of the Study:

  • To develop and validate an endoscopic implementation of 3D single snapshot of optical properties (3D-SSOP).
  • To provide quantitative maps of absorption, reduced scattering, and surface topography.
  • To enhance surgical guidance in minimally invasive procedures.

Main Methods:

  • Integrated 3D-SSOP technique with a commercial endoscope.
  • Utilized simple, added instrumentation for widefield optical imaging.
  • Validated system accuracy and precision using tissue-mimicking phantoms.

Main Results:

  • Achieved quantitative mapping of absorption (max error 0.004 mm-1) and reduced scattering (max error 0.05 mm-1).
  • Provided accurate surface topography measurements (max error 1.1 mm).
  • Demonstrated real-time video acquisition of moving phantoms and in vivo samples at ~11 fps.

Conclusions:

  • The endoscopic 3D-SSOP system offers a feasible solution for quantitative optical property and topography mapping.
  • This technology has the potential to significantly improve surgical guidance in minimally invasive procedures.
  • The system's validated accuracy and real-time capabilities support its clinical translation.