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Natural Bioactive New Withanolides.

Qian-Qian Xu1, Kui-Wu Wang1

  • 1Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.

Mini Reviews in Medicinal Chemistry
|December 1, 2017
PubMed
Summary
This summary is machine-generated.

Recent research has identified over 170 new natural withanolides, complex steroids with diverse biological activities. This review summarizes their structures and pharmacological effects.

Keywords:
Withanolideanti-inflammatoryantistressbiological activitiesoxygenated steroidsstructure

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Withanolides are a class of highly oxygenated steroids based on a C28 ergostane skeleton.
  • These compounds are recognized for their intricate structural characteristics and a wide spectrum of biological effects.
  • Significant scientific interest surrounds withanolides due to their therapeutic potential.

Purpose of the Study:

  • To provide a comprehensive overview of newly identified natural withanolides.
  • To summarize the structural elucidation of these compounds.
  • To review the documented biological and pharmacological activities of recent withanolide discoveries.

Main Methods:

  • Literature review of scientific publications from the last five years.
  • Analysis of reported isolation and characterization techniques for natural products.
  • Compilation and synthesis of data on biological assays and pharmacological evaluations.

Main Results:

  • Over 170 novel natural withanolides have been isolated and structurally identified in the past five years.
  • These new compounds exhibit diverse and significant bioactivities.
  • Detailed structural features contributing to their bioactivity have been elucidated.

Conclusions:

  • The field of withanolide research has expanded significantly with numerous new discoveries.
  • Recent withanolides represent a rich source of potential therapeutic agents.
  • Further investigation into the structure-activity relationships of these compounds is warranted.