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A simple hand-held magnet array for efficient and reproducible SABRE hyperpolarisation using manual sample shaking.

Peter M Richardson1, Scott Jackson1, Andrew J Parrott2

  • 1Centre for Hyperpolarisation in Magnetic Resonance (CHyM), Department of Chemistry, University of York, York, UK.

Magnetic Resonance in Chemistry : MRC
|December 2, 2017
PubMed
Summary
This summary is machine-generated.

A new method uses a handheld magnet array for signal amplification by reversible exchange (SABRE) hyperpolarization. This technique enhances NMR signal reproducibility and efficiency, especially for benchtop instruments.

Keywords:
1HHalbach arrayNMRbenchtop NMRhyperpolarisationparahydrogenpolarisation transfer fieldsignal amplification by reversible exchange (SABRE)

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Area of Science:

  • Hyperpolarization techniques
  • Nuclear Magnetic Resonance (NMR) spectroscopy
  • Catalysis

Background:

  • Signal amplification by reversible exchange (SABRE) is a hyperpolarization method transferring nuclear polarization from parahydrogen to substrates.
  • SABRE requires a polarization transfer field (PTF) before detection in a stronger magnetic field.
  • Current methods using stray fields are often irreproducible and incompatible with benchtop NMR.

Purpose of the Study:

  • To develop a more reproducible and accessible method for generating the PTF for SABRE.
  • To improve SABRE enhancement efficiency, particularly for benchtop NMR instruments.
  • To enable rapid optimization of SABRE parameters by varying the PTF.

Main Methods:

  • Utilized a simple hand-held permanent magnet array to provide the PTF during sample shaking.
  • Compared enhancements achieved with the magnet array to those using superconducting magnet stray fields.
  • Tested arrays with varying PTFs and compared results to an automated flow system with an electromagnet.

Main Results:

  • The permanent magnet array increased SABRE enhancement by 25% compared to the stray field method.
  • The new approach demonstrated improved reproducibility in SABRE experiments.
  • PTF-dependent enhancements correlated well with results from an automated flow system.

Conclusions:

  • A hand-held permanent magnet array provides an efficient and reproducible method for SABRE hyperpolarization.
  • This technique is particularly beneficial for benchtop NMR spectrometers lacking strong stray fields.
  • The ability to tune the PTF facilitates rapid optimization for new SABRE applications.