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Updated: Feb 17, 2026
Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
Published on: December 8, 2023
Endoscopic Corneal Neurotization: Technique and Initial Experience.
Ilya Leyngold1, Christopher Weller1, Mark Leyngold1
1Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, Duke University Hospital, Durham, North Carolina, U.S.A.
This study presents a minimally invasive endoscopic surgery to restore corneal sensation using the supraorbital nerve in patients with neurotrophic keratopathy, achieving successful nerve regeneration and corneal healing.
Area of Science:
- Ophthalmology
- Neurosurgery
- Regenerative Medicine
Background:
- Neurotrophic keratopathy (NK) is a serious eye condition characterized by impaired corneal healing and sensation.
- Current treatments for NK can be invasive and may not fully restore corneal function.
Observation:
- A novel endoscopic surgical technique was employed to harvest a pedicled contralateral supraorbital nerve.
- The harvested nerve was endoscopically transferred to the affected eye to re-establish corneal innervation.
Findings:
- Successful endoscopic corneal neurotization was achieved, restoring corneal sensibility.
- Corneal epithelial integrity was regained following the procedure.
Implications:
- This minimally invasive endoscopic approach offers a promising new treatment for neurotrophic keratopathy.
- Supraorbital nerve grafting via endoscopy represents a significant advancement in corneal regenerative surgery.
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