Related Experiment Video
Updated: Feb 17, 2026
08:18
Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
1.6K
Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability
Vineet Kumar Rai1, Nidhi Mishra1, Kuldeep Singh Yadav1
1CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, U.P., India.
Summary
Nanoemulsions enhance drug delivery through the skin. Optimizing semisolid formulations using factors like particle size and zeta potential is key for effective dermal and transdermal applications.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Nanotechnology
Background:
- Nanoemulsions are established for enhancing dermal and transdermal drug delivery.
- Developing nanoemulsion-based semisolid dosage forms is a current research focus.
- Semisolid conversion of nanoemulsions presents formulation challenges and opportunities.
Purpose of the Study:
- To review advancements in nanoemulsion-based dermal and transdermal drug delivery.
- To explore suitable semisolid bases for different nanoemulsion types (o/w, w/o).
- To investigate the impact of particle size and zeta potential on drug delivery.
Main Methods:
- Literature review of nanoemulsion-based semisolid dosage forms.
- Analysis of factors influencing dermal/transdermal drug absorption.
- Discussion of manufacturing principles and formulation considerations.
Main Results:
- Nanoemulsion properties like zeta potential and particle size significantly affect drug delivery efficiency.
- Selection of appropriate semisolid bases is crucial for stable nanoemulsion formulations.
- Understanding these factors facilitates the transition from lab to industrial scale.
Conclusions:
- Optimizing nanoemulsion characteristics and formulation strategies is vital for effective dermal and transdermal drug delivery.
- Further research into semisolid bases and formulation stability is warranted.
- Nanoemulsion-based semisolid dosage forms offer promising avenues for drug delivery applications.
More Related Videos
Related Concept Videos
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.8K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.8K
01:27Bioavailability Enhancement: Drug Permeability Enhancement
218
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
218
01:16Drug Delivery: Overview
949
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
949
01:18Transdermal Drug Delivery Systems
29
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
29
01:27Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
189
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
189
01:20Modified-Release Drug Delivery Systems: Influencing Factors
23
Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
23