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Updated: Feb 17, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Antibiotic overprescribing: Still a major concern

David C Fiore1, Lacy P Fettic1, Stephanie D Wright1

  • 1Department of Family and Community Medicine, University of Nevada, Reno School of Medicine, Reno, NV, USA.

The Journal of Family Practice
|December 5, 2017
PubMed

Insights

Antibiotic overprescribing is a significant problem, contributing to antimicrobial resistance and increased healthcare costs. Addressing this issue is crucial to prevent a post-antibiotic era where common infections could become lethal.

Area of Science:

  • Medical Science
  • Public Health
  • Infectious Diseases

Background:

  • Antibiotic overprescribing is a widespread issue despite global recognition.
  • Inappropriate antibiotic use drives antimicrobial resistance, disrupts the gut microbiome, and increases healthcare expenses.
  • A significant percentage of outpatient antibiotic prescriptions are unnecessary, exacerbating the problem.

Purpose of the Study:

  • To highlight the critical problem of antibiotic overprescribing.
  • To underscore the severe consequences of antimicrobial resistance.
  • To identify actionable strategies for frontline healthcare providers.

Main Methods:

  • Review of existing reports and data on antibiotic prescribing practices.
  • Analysis of the link between antibiotic use and adverse health outcomes.
  • Focus on the role of family practitioners in combating overprescribing.

Main Results:

  • At least 30% of outpatient antibiotic prescriptions in the US are unnecessary.
  • Limited development of new drugs targeting resistant bacteria poses a future threat.
  • The potential for a post-antibiotic era, where common infections are untreatable, is a serious concern.

Conclusions:

  • Urgent action is needed to curb antibiotic overprescribing.
  • Family practitioners play a vital role in implementing solutions.
  • Strategies to reduce unnecessary antibiotic use are essential for public health.

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