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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
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Single fraction stereotactic radiosurgery for multiple brain metastases.
Dror Limon1, Frances McSherry2, James Herndon2
1Department of Oncology, Rabin Medical Center, Petah-Tikva, Israel.
Advances in Radiation Oncology
|December 6, 2017
Summary
Stereotactic radiosurgery (SRS) for multiple brain metastases (BM) shows improved survival with smaller tumor volumes and higher doses. Treatment outcomes depend more on total tumor volume than lesion count.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Physics
Background:
- Whole brain radiation therapy (WBRT) has neurocognitive side effects.
- Stereotactic radiosurgery (SRS) is increasingly used for multiple brain metastases (BM).
- SRS use is expanding for patients with more than four BM.
Purpose of the Study:
- Summarize institutional experience with single-fraction SRS for multiple BM.
- Evaluate factors influencing survival in patients with multiple BM treated with SRS.
Main Methods:
- Retrospective, single-institution study of 59 patients with ≥4 BM treated with single-fraction SRS.
- Linear accelerator-based, image-guided SRS was used.
- Median follow-up was 15.2 months.
Main Results:
- Median overall survival was 5.8 months.
- Better survival observed for total tumor volume <10 cc (7.1 months) vs. ≥10 cc (4.2 months).
- Higher mean dose to PTV (≥19 Gy) and lower volume of normal brain receiving >12 Gy were associated with increased survival.
Conclusions:
- Single-fraction SRS is efficacious for multiple BM.
- Smaller total tumor volume and higher radiation dose correlate with increased survival.
- Outcomes may be more influenced by total tumor volume than by the number of lesions.
