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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
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Paternal HLA-C is a risk factor in unexplained recurrent miscarriage.

Tess Meuleman1, Geert W Haasnoot2, Jan M M van Lith1

  • 1Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|December 6, 2017
PubMed
Summary

Human Leukocyte Antigen C (HLA-C) incompatibility between couples is linked to unexplained recurrent miscarriage. This finding suggests a role for the immune system in pregnancy loss.

Keywords:
HLA-Cpregnancyrecurrent miscarriage

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Area of Science:

  • Immunogenetics
  • Reproductive Immunology
  • Obstetrics

Background:

  • Human Leukocyte Antigen C (HLA-C) is the sole classical HLA-I antigen on trophoblast.
  • The maternal alloimmune response to paternal HLA-C is a potential factor in unexplained recurrent miscarriage (URM).

Purpose of the Study:

  • To investigate the association between HLA-C incompatibility and URM.
  • To determine the role of specific immunogenic HLA-C alleles and antibodies in URM.

Main Methods:

  • A case-control study involving 100 women with URM and their partners/children.
  • Control groups included 90 women with uncomplicated pregnancies and 425 families.
  • Analysis of HLA-C, HLA-C*07, HLA-C*17 frequencies, HLA-C mismatches, and maternal HLA antibodies.

Main Results:

  • Significantly increased frequencies of HLA-C and HLA-C*07 mismatches in couples with URM compared to controls.
  • Elevated incidence of child-specific HLA-C*07/HLA-C*17 antibodies in women experiencing URM.

Conclusions:

  • HLA-C incompatibility between partners is significantly associated with unexplained recurrent miscarriage.
  • Immune responses to paternal HLA-C antigens may contribute to pregnancy loss in URM.