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Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Veins of Head and Neck

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The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
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Related Experiment Video

Updated: Feb 17, 2026

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

Published on: October 2, 2014

Suprachoroidal shunts.

¹Department of Ophthalmology, Icahn School of Medicine at Mount Sinai and New York Eye and Ear Infirmary of Mount Sinai, New York, New York, USA.

Current Opinion in Ophthalmology

|December 6, 2017

Summary

This summary is machine-generated.

New suprachoroidal shunts show promise for lowering eye pressure in open-angle glaucoma patients. These glaucoma implants offer a favorable safety profile, but long-term effectiveness requires further study.

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Area of Science:

Ophthalmology
Glaucoma Surgery
Medical Devices

Background:

Open-angle glaucoma management often requires reducing intraocular pressure.
The suprachoroidal space offers a potential pathway for novel glaucoma drainage devices.
Ab interno and ab externo suprachoroidal shunts are being developed to enhance uveoscleral outflow.

Purpose of the Study:

To review recent studies on the efficacy and safety of ab externo and ab interno suprachoroidal shunts.
To evaluate these devices for augmenting uveoscleral outflow in open-angle glaucoma patients.

Main Methods:

Review of recent clinical studies and trials.
Analysis of data on suprachoroidal shunt devices including Gold Shunt, STARflo, CyPass Micro-Stent, and iStent Supra.
Evaluation of surgical approaches: ab externo and ab interno.

Main Results:

Suprachoroidal shunts demonstrate potential for lowering intraocular pressure to the mid-to-high teens.
Devices like CyPass Micro-Stent showed improved efficacy when combined with cataract surgery.
A favorable safety profile is suggested for these devices, with reduced medication burden.
Long-term success may be limited by fibroblastic proliferation in the suprachoroidal space.

Conclusions:

Biocompatible glaucoma implants targeting the suprachoroidal space are emerging.
Ab interno devices offer advantages in combining with cataract surgery and preserving conjunctiva.
Further research is necessary to determine the long-term efficacy and potential complications of suprachoroidal shunts.