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A new12-membered lactone from the stems of Ficus auriculata
Tai-Ming Shao1,2, Cai-Juan Zheng1, Xiao-Bao Li1
1a Key Labortory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering , Hainan Normal University , Haikou , P. R. China.
Abstract:
A new lactone ficusine D (1), together with six known compounds (2-7) were isolated from the stems of the Ficus auriculata. The new compound 1 was a rare 12-membered lactone containing a quinone ring skeleton. The structure of the 1 was elucidated by comprehensive spectroscopic data. The relative and absolute configurations of 1 were elucidated by the ROESY analysis and biogenesis pathway. All compounds were evaluated for their antibacterial activities against six pathogenic bacteria in vitro. Compounds 6 and 7 exhibited potent antibacterial activities against Bacillus cereus with the MIC values of 2.5 and 5 μM, respectively.
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