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Related Experiment Videos

T Nguyen1, N Castex-Rizzi1, D Redoulès1

  • 1Pierre Fabre Dermo-Cosmétique, Centre de recherche & développement Pierre Fabre, 3, avenue Hubert-Curien, 31035 Toulouse cedex, France.

Annales De Dermatologie Et De Venereologie
|December 10, 2017
PubMed
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A novel biological extract, I-modulia®, demonstrates significant anti-inflammatory and anti-pruritus effects for atopic dermatitis (AD). This extract modulates innate immunity and restores immune homeostasis, offering a promising alternative treatment for AD.

Area of Science:

  • Dermatology
  • Immunology
  • Biotechnology

Background:

  • Atopic dermatitis (AD) is a complex inflammatory skin condition requiring alternative treatments beyond topical steroids.
  • The need for novel therapeutic strategies for AD is driven by its multifactorial origin and the limitations of current treatments.

Purpose of the Study:

  • To evaluate the pharmacological activities of a novel biological extract, I-modulia®, derived from Aquaphilus dolomiae.
  • To investigate the potential of I-modulia® as an alternative treatment for atopic dermatitis.

Main Methods:

  • In vitro evaluation of I-modulia® using human keratinocytes and dendritic cells exposed to Staphylococcus aureus secretomes.
  • Assessment of I-modulia®'s effects on innate immunity, cytokine profiles, and T helper cell responses.
Keywords:
Atopic dermatitisDermatite atopiqueImmunomodulationKeratinocytesKératinocytesPruritPruritus

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  • Analysis of I-modulia®'s impact on Protease-activated-receptor 2 (PAR2) and Thymic-stromal-lymphopoeitin (TSLP) pathways.

    • Main Results:

    • I-modulia® demonstrated innate immunity modulation by agonizing Toll-like receptors (TLR) 2, 4, and 5.
    • The extract induced antimicrobial peptides and inhibited key cytokines associated with T helper (Th)1, Th2, and Th17 responses.
    • I-modulia® inhibited PAR2 and TSLP, known contributors to pruritus, and induced IL-10 secretion in dendritic cells, promoting T lymphocyte regulation and tolerogenicity.

    Conclusions:

    • I-modulia®, a biotech-derived extract, exhibits significant anti-inflammatory and anti-pruritus properties.
    • The extract restores immune homeostasis and ameliorates atopic dermatitis symptoms, particularly in young infants.
    • I-modulia® represents a promising therapeutic agent for atopic dermatitis management.