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Updated: Feb 17, 2026

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

3D Bioprinting of Murine Cortical Astrocytes for Engineering Neural-Like Tissue

Published on: July 16, 2021

Bioprinting for Neural Tissue Engineering.

Stephanie Knowlton¹, Shivesh Anand², Twisha Shah³

¹Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; These authors contributed equally.

Trends in Neurosciences

|December 11, 2017

Summary

This summary is machine-generated.

Bioprinting enables the creation of 3D neural tissues, offering a better model than 2D cultures for studying neural cells and diseases. This technology precisely controls the microenvironment for developing therapies and replacement tissues.

Keywords:

biofabrication bioprinting neural tissue engineering neurological disease regenerative medicine

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Area of Science:

Biotechnology
Neuroscience
Tissue Engineering

Background:

Two-dimensional (2D) neural cultures are widely used but do not fully replicate the complex microenvironment of neural tissues.
Three-dimensional (3D) cultures offer a more accurate representation of in vivo neural tissue architecture and cellular interactions.

Purpose of the Study:

To review the current state-of-the-art approaches for bioprinting neural tissues.
To highlight the potential of bioprinting in advancing neural research and therapeutic development.

Main Methods:

Utilizing cell-encapsulating bioinks to pattern and create complex 3D neural tissue constructs.
Precisely controlling the cellular microenvironment through bioink formulation and spatial patterning of cell types and scaffold properties.

Main Results:

Bioprinting allows for the precise fabrication of 3D neural constructs that mimic native tissue environments.
This technology facilitates the development of advanced models for observing neuronal behavior and disease pathology.

Conclusions:

Bioprinting neural tissues offers significant advantages over traditional 2D cultures for neural research.
This technology holds promise for understanding neurological diseases, developing novel therapies, and engineering replacement neural tissues.