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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Breakthroughs in neuroactive steroid drug discovery

Maria-Jesus Blanco1, Daniel La1, Quinn Coughlin1

  • 1Sage Therapeutics, Inc., 215 First Street, Cambridge, MA 02142, USA.

Bioorganic & Medicinal Chemistry Letters
|December 11, 2017
PubMed
Summary

Neuroactive steroids modulate key brain receptors, offering new hope for neurological disorders. Research highlights clinical progress and novel compounds targeting GABAA and NMDA receptors.

Keywords:
Clinical candidateExtrasynapticGABA(A)NASNMDANeurosteroidSynaptic

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