[PATHOGENETIC FEATURES OF THE DEVELOPMENT OF OVERACIVE BLADDER IN WOMEN]

The aim of the research was to study the pathogenetic features of the development of the overactive bladder (OAB) in women. 107 women with OAB and a control group of 29 healthy women were involved into the study. The hormonal status was studied based on the determination of serum concentrations of luteinizing hormone (LH), stimulating hormone (FSH), estradiol and progesterone. The urine levels of interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-8 (IL-8), tumor necrosis factor ά (TNF-ά) and macrophage chemotactic protein-1 (MCP-1) were assessed. Decreased level of estradiol was detected in 26.47% of women of reproductive age. Elevated urine levels of MCP-1 and IL-8 were found in 35.5% of patients. The obtained data testify to the possible pathogenetic role of inflammatory changes in the bladder wall, as well as hypoestrogenism in women of reproductive age in the development of OAB.