[ADAPTIVE REGULATORY MECHANISMS OF ALOPECIA AREATA]

Failure of adaptive mechanisms leads to structural and functional damage at all levels and of neuroendocrinal and immune systems, which are pathogenetic basis of development of autoimmune diseases, in particular. The objective of this work was to assess the condition of adaptive hormones, such as cortisol and insulin, coefficient of stress of adaptive potential "K" and also dermatologic life quality index (DLQI) of the diseased with alopecia areata (AA). 48 patients with different forms of AA aged between 18 and 52 were examined. Correlation analysis identified positive correlation between DLQI and early age of patients, severe stage and hair loss for the period of over 12 months (p<0.01). Two types of reactions were identified - increase and decrease of content of cortisol and insulin in blood depending on the activity, severity stage and length of AA. The diseased with signs of progression of the disease, severe stage and duration of up to 3 years AA experienced increase of the coefficient "K" (p<0.05) indicates increase of tension of adaptive potential of the organism. Decrease of the coefficient "K" (p<0.05) during chronisation and duration of the disease of over 3 years indicates depletion of adaptive mechanisms of organism with possible failure of regulatory processes. Identified disorders demonstrate existence of maladaptive processes in the diseased with FF and may be considers as potential therapeutic targets.