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Related Concept Videos

Development of the Sexual Organs in the Embryo and Fetus01:15

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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
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Accessory Glands of the Male Reproductive System01:16

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The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
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Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
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Testosterone: Functions and Regulation01:26

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Establishment and Maintenance of Patient-derived Prostate Cancer Organoids: A Detailed Experimental Protocol
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Prostate Organogenesis.

Jeffrey C Francis1, Amanda Swain1

  • 1Division of Cancer Biology, Institute of Cancer Research, London SW3 6JB, United Kingdom.

Cold Spring Harbor Perspectives in Medicine
|December 13, 2017
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Summary
This summary is machine-generated.

Prostate development research reveals genes crucial for organ formation are often reactivated in prostate cancer. Understanding these links informs new therapeutic strategies for this prevalent male cancer.

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Area of Science:

  • Urology
  • Developmental Biology
  • Oncology

Background:

  • Prostate tumors are a leading cancer in men, with origins linked to developmental processes.
  • Genes and signaling pathways essential for prostate organogenesis can be reactivated or dysregulated in cancer.
  • Prostate development involves stages like organ specification, budding, branching morphogenesis, and cytodifferentiation, regulated by androgens.

Purpose of the Study:

  • To review genes critical for prostate development.
  • To explore the link between these developmental genes and prostate tumorigenesis.
  • To highlight how understanding organogenesis informs prostate cancer mechanisms.

Main Methods:

  • Literature review of studies on prostate development.
  • Analysis of gene expression and signaling pathways in prostate development and cancer.
  • Correlation of developmental gene roles with prostate cancer evidence.

Main Results:

  • Specific genes and signaling pathways are vital for normal prostate organogenesis.
  • These same genes/pathways are frequently implicated in the development and progression of prostate tumors.
  • Androgen regulation during development mirrors hormone sensitivity in most prostate cancers.

Conclusions:

  • Prostate organogenesis and cancer share common molecular underpinnings.
  • Genes involved in prostate development are key targets for understanding and treating prostate cancer.
  • Therapeutic strategies targeting hormone regulation, like antiandrogen therapy, are informed by developmental biology.