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Updated: Feb 17, 2026

Murine Kidney Transplant Technique
Published on: October 20, 2015
Unusual Pathology in a Kidney from a Heart-Transplant Patient
Marie Larcher1, Audey Delas2,3, Clément Delmas4
1Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
Abstract:
Acute kidney injury (AKI) is often observed after heart transplantation. In this setting, acute tubular necrosis is the main histological finding on kidneys. We report the unusual pathology found in a kidney from a heart-transplant patient. The patient experienced several hemodynamic insults, massive transfusion, and implantation of a mechanical circulatory-support device before heart transplantation: there was prolonged AKI after transplantation. A kidney biopsy revealed acute tubular necrosis and renal hemosiderosis, which was probably related to the transfusion and to mechanical circulatory-support device-induced intravascular hemolysis. Assessment of iron during resuscitation could have prevented, at least partly, AKI.
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