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[Cefazolin and coagulation disorders: a case report]
Eugénie Gay1, Anne Barthel1, Nicolas Rouzic2
1Laboratoire de biologie polyvalente.
Annales De Biologie Clinique
|December 13, 2017
Summary
Cefazolin, an antibiotic, may cause dangerous bleeding by lowering vitamin K-dependent clotting factors. Prompt vitamin K administration can reverse these effects, alerting clinicians to this potential complication.
Area of Science:
- Infectious Diseases
- Pharmacology
- Hematology
Background:
- A 79-year-old patient presented with calcaneal osteitis and pacemaker lead endocarditis.
- Treatment involved intravenous cefazolin, an antibiotic targeting methicillin-sensitive Staphylococcus aureus.
Observation:
- During cefazolin treatment, the patient experienced a decrease in prothrombin time and vitamin K-dependent factors.
- This occurred in the absence of anticoagulant therapy, suggesting a direct drug effect.
Findings:
- The patient developed bleeding complications at the calcaneal osteitis site.
- Administration of vitamin K successfully normalized prothrombin time and vitamin K-dependent factors.
Implications:
- This case highlights a potential, underreported adverse effect of cefazolin on coagulation.
- Clinicians and pathologists should be vigilant for coagulation disorders in patients receiving cefazolin.
- Further investigation into cefazolin's impact on vitamin K metabolism is warranted.
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