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Related Experiment Video

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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
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The artificial membrane insert system as predictive tool for formulation performance evaluation.

Philippe Berben1, Joachim Brouwers1, Patrick Augustijns1

  • 1Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - Box 921, 3000 Leuven, Belgium.

International Journal of Pharmaceutics
|December 16, 2017
PubMed
Summary
This summary is machine-generated.

The artificial membrane insert system (AMI-system) effectively predicts drug absorption from formulations. This cell-free model aids early-stage evaluation of absorption-enabling drug formulations.

Keywords:
Artificial membrane insert system (AMI-system)Formulation evaluationIn vivo in vitro approachPermeation potentialSolubility-permeability interplaySupersaturation

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery
  • Biopharmaceutics

Background:

  • Pharmaceutical companies increasingly seek cell- and tissue-free models for formulation testing.
  • Evaluating drug permeation is crucial for formulation development and predicting in vivo performance.

Purpose of the Study:

  • To assess the artificial membrane insert system (AMI-system) as a predictive tool for absorption-enabling formulations.
  • To explore the AMI-system's capability in supersaturation assessment and formulation evaluation.

Main Methods:

  • Permeation studies were conducted using the AMI-system with varying degrees of loviride supersaturation.
  • A two-stage dissolution test preceded permeation assessment for formulation evaluation.
  • Case studies included posaconazole, itraconazole, and fenofibrate formulations with available in vivo data.

Main Results:

  • The AMI-system successfully captured the impact of loviride supersaturation on drug permeation.
  • The system accurately predicted formulation pH effects on posaconazole absorption.
  • It correctly predicted dilution effects on itraconazole absorption and food intake effects on fenofibrate absorption.

Conclusions:

  • The AMI-system, coupled with dissolution testing, offers a time- and cost-effective early-stage evaluation method.
  • This in vivo/in vitro approach supports the development of advanced drug delivery systems.
  • The AMI-system demonstrates significant potential for predicting drug performance in formulation testing.