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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
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Constrained cell penetrating peptides.
1Radboud University Nijmegen, Institute for Molecules and Materials, Bio-organic Chemistry, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Drug Discovery Today. Technologies
|December 19, 2017
Summary
Researchers are developing methods to control cell-penetrating peptides (CPPs) for better drug delivery. This review covers strategies like triggerable activation, backbone rigidification, and macrocyclization to enhance CPP transduction properties and selectivity.
Area of Science:
- Biochemistry
- Molecular Biology
- Drug Delivery Systems
Background:
- Cell-penetrating peptides (CPPs) facilitate the entry of molecules into cells.
- Controlling CPP transduction properties remains a significant challenge in their application.
- Enhanced CPPs are crucial for targeted intracellular delivery.
Purpose of the Study:
- To review recent advancements in controlling CPP transduction properties.
- To present strategies for restraining CPPs to improve their activity and selectivity.
- To highlight the potential of constrained CPPs in biomedical research.
Main Methods:
- Overview of recent developments in CPP research.
- Discussion of three distinct CPP constraining strategies: triggerable activation, backbone rigidification, and macrocyclization.
- Analysis of the opportunities presented by each method for controlling CPP behavior.
Main Results:
- Recent research focuses on restraining CPPs to modulate their function.
- Triggerable activation, backbone rigidification, and macrocyclization offer distinct approaches to control CPPs.
- These strategies aim to enhance CPPs' efficiency and specificity in cellular uptake.
Conclusions:
- Constraining CPPs is a promising avenue for improving their utility.
- The presented strategies offer new possibilities for designing advanced CPPs.
- Further research into these methods can lead to more effective CPP-based therapeutics and research tools.
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