[Interstitial volume receptors of the liver]

The study of the impulse activity of single afferent hepatic fibers in depth has found out that there are volume-sensitive units reacting upon the short-time infusion of the different test solutions into the portal vein. But they are displaying complex dependence of the response's characteristics not only on the magnitude increasing in intraportal volume but also on "quality" of the infused substance and total quantity of the injected fluid. There are units both responding for infusion period and after it with the latencies from 10 s to 2-3 min. The second phase of these units responses was more pronounced than the first one. The response patterns of the studied units are convincing data on an interstitial localization of the one type volumereceptors and a vasal-interstitial localization of the others. The results suggest that the significant role in the control of the water-salt homeostasis is played by these receptors.