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Updated: Feb 16, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Diverse ring opening of thietanes and other cyclic sulfides: an electrophilic aryne activation approach
Tianyu Zheng1, Jiajing Tan, Rong Fan
1Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China. tanjj@mail.buct.edu.cn.
Abstract:
Organosulfides are a common class of structure units in bioactive molecules and functional materials motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of one or two heteroatom containing saturated sulfur heterocycles. This three-component transformation proceeds under mild reaction conditions and displays exceptional generality of nucleophiles (C, O, S, N, and F centered nucleophiles), giving structurally diverse thioethers in good yields.
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