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Updated: Feb 16, 2026

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
Published on: May 27, 2022
Leydig cell tumor of the testis, presenting with azoospermia
Hatsuki Hibi1, Kyoko Yamashita2, Makoto Sumitomo3
1Department of Urology Kyoritsu General Hospital Nagoya Japan.
Case:
A case of Leydig cell tumor, associated with azoospermia, is presented.
Outcome:
The levels of sex hormones obviously were decreased, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), with elevated testosterone. Computed tomography revealed no adrenal gland tumor, but a significant calcification in the right scrotal content was observed. He received a right radical orchiectomy and then he was unable to ejaculate. An endocrine panel revealed significantly decreased levels of testosterone and the low LH level had remained. Hormone replacement therapy with combined LH and FSH successfully recovered and preserved spermatogenesis.
Conclusions:
Although the patient's sexual function deteriorated after surgery, hormone replacement therapy was successful in establishing spermatogenesis.
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