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Calbindin-D immunolocalization in developing chick thyroid: a light and electron microscopic study.

N Inpanbutr1, A N Taylor

  • 1Department of Anatomy, Baylor College of Dentistry, Dallas, Texas 75246.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
|April 1, 1989
PubMed
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Calbindin-D, a vitamin D-dependent calcium-binding protein, appears in developing chick thyroid cells early in embryogenesis. Its presence and localization suggest a role in thyroid development.

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Cell Biology

Background:

  • Calbindin-D is a 28-kilodalton (KD) vitamin D-dependent calcium-binding protein.
  • Thyroid development involves complex cellular differentiation processes.

Purpose of the Study:

  • To immunocytochemically localize calbindin-D in the developing chick thyroid.
  • To investigate the temporal and spatial distribution of calbindin-D during chick thyroid development.

Main Methods:

  • Immunocytochemistry using antiserum to calbindin-D.
  • Light and electron microscopy were employed for protein localization.
  • Analysis of chick embryos at various developmental stages (from 8 days to just before hatching).

Main Results:

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  • Calbindin-D was first detected in future follicular cells of 8-day-old chick embryos.
  • The protein concentration increased rapidly by day 10, plateaued until day 15, and then decreased before hatching.
  • Calbindin-D was found in the cytoplasm and nucleus of follicular cells, but not in the follicular colloid.

Conclusions:

  • The temporal expression pattern of calbindin-D correlates with known thyroid follicular cell differentiation.
  • Calbindin-D may play a role in the yet-to-be-determined mechanisms of normal thyroid development.