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Updated: Feb 16, 2026

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
[Mathematical modeling: an essential tool for the study of therapeutic targeting in solid tumors]
Zuzana Saidak1, Anne-Sophie Giacobbi2, Mony Chenda Morisse3
1Laboratoire d'oncobiologie moléculaire, Centre de biologie humaine (CBH), CHU Amiens Sud, Amiens, France.
Abstract:
Recent progress in biology has made the study of the medical treatment of cancer more effective, but it has also revealed the large complexity of carcinogenesis and cell signaling. For many types of cancer, several therapeutic targets are known and in some cases drugs against these targets exist. Unfortunately, the target proteins often work in networks, resulting in functional adaptation and the development of resilience/resistance to medical treatment. The use of mathematical modeling makes it possible to carry out system-level analyses for improved study of therapeutic targeting in solid tumours. We present the main types of mathematical models used in cancer research and we provide examples illustrating the relevance of these approaches in molecular oncobiology.
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