Validation of the GLI-2012 spirometry reference equations in Argentinian children

Area of Science:

• Pediatric Pulmonology
• Respiratory Medicine
• Global Health

Background:

• The Global Lung Function Initiative (GLI) provides spirometry reference equations across diverse ethnic groups.
• Previous studies indicate GLI equations may not universally represent all populations, potentially misclassifying lung function.
• Validating GLI equations in local populations is crucial before clinical implementation.

Purpose of the Study:

• To assess the applicability of GLI spirometry reference equations in a pediatric population in Argentina.
• To determine if GLI equations accurately reflect lung function parameters in Argentinian children.

Main Methods:

• Spirometry data were collected from 2072 healthy Argentinian children aged 3.0-12.4 years.
• Global Lung Function Initiative (GLI) "Caucasian" and "other/mixed" race equations were used to calculate Z-scores.
• Lung function parameters including FVC, FEV1, FEV0.75, and FEF25-75 were analyzed.

Main Results:

• GLI "Caucasian" equations demonstrated good fit with Z-scores close to zero for Argentinian children.
• GLI "other/mixed" race equations showed a less accurate fit.
• Using the "Caucasian" equation, abnormal lung function was identified in 3.9-6.8% of healthy children, aligning with expected values.

Conclusions:

• The GLI-2012 "Caucasian" spirometry reference equations are suitable for use in Argentinian children.
• These validated equations can be reliably applied in pediatric spirometry assessments within Argentina.