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Chromanopyrones and a flavone from Hypericum monogynum.

Yan-Rong Zeng1, Li-Ping Wang1, Zhan-Xing Hu2

  • 1State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China; School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, People's Republic of China.

Fitoterapia
|December 23, 2017
PubMed
Summary
This summary is machine-generated.

Researchers isolated six new compounds from Hypericum monogynum, evaluating their potential as alpha-glucosidase inhibitors and antioxidants. Compounds 1, 5, and 7 demonstrated moderate inhibitory activity against alpha-glucosidase.

Keywords:
Anti-oxidant activityHypericum monogynumInhibitory effects on α-glucosidasePyrone derivatives

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Hypericum monogynum is a plant species known for its diverse chemical constituents.
  • Natural products are a rich source of potential therapeutic agents.
  • Alpha-glucosidase inhibitors are important targets for managing type 2 diabetes.

Purpose of the Study:

  • To isolate and characterize new and known compounds from Hypericum monogynum.
  • To evaluate the inhibitory effects of isolated compounds on alpha-glucosidase.
  • To assess the antioxidant activity of the isolated compounds.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation through extensive spectroscopic data analysis (NMR, MS).
  • Determination of absolute configurations using Electronic Circular Dichroism (ECD) calculations.
  • Enzyme inhibition assays to determine IC50 values for alpha-glucosidase inhibition.
  • Antioxidant activity assays.

Main Results:

  • Six new compounds, including pyrone derivatives, a flavone, and two naturally-occurring compounds, were isolated along with 16 known compounds.
  • Compounds 2-4 were identified as racemates.
  • Compounds 1, 5, and 7 exhibited moderate alpha-glucosidase inhibitory activities with IC50 values of 161.46, 257.78, and 11.54 μg/ml, respectively.
  • Compound 8 showed weak antioxidant activity with an IC50 value of 12.55 μg/ml.

Conclusions:

  • The study successfully identified novel and known compounds from Hypericum monogynum.
  • Several isolated compounds possess moderate potential as alpha-glucosidase inhibitors.
  • The findings contribute to the understanding of the phytochemical profile and bioactivity of Hypericum monogynum.