Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

6
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
6
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

17
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
17
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

21
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
21
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

18
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
18
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

21
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
21
Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

23
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disposable Endoscope Cap Maintaining Clear Surgical Visualization under Fogging and Fouling.

ACS applied materials & interfaces·2026
Same author

Reversible congestive heart failure associated with diabetes mellitus in two cats.

JFMS open reports·2026
Same author

Spinal cord extracellular matrix hydrogel enhances organoid maturation and functional regeneration after spinal cord injury.

Materials today. Bio·2026
Same author

Targeted KEAP1 disruption enhances antioxidant defense and mesenchymal stromal cell therapy for chronic limb-threatening ischemia.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Adhesive Hydrogel Inks with Boronic Acid-Cis-Diol Complexation for On-Muscle Printing.

Tissue engineering. Part A·2026
Same author

Pathological Nitric Oxide-Triggered Microneedle Patch for Spatiotemporally Controlled Therapy of Acute and Chronic Inflammatory Disorders.

Advanced healthcare materials·2026

Related Experiment Video

Updated: Feb 16, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

14.2K

Microchannel system for rate-controlled, sequential, and pH-responsive drug delivery.

Dasom Yang1, Jung Seung Lee2, Chang-Kuk Choi1

  • 1Department of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.

Acta Biomaterialia
|December 23, 2017
PubMed
Summary

Microchannels offer precise control over drug delivery rates, sequences, and environmental responsiveness. This study demonstrates how microchannel geometry can be engineered for predictable and customizable therapeutic molecule release.

Keywords:
Diffusion based drug deliveryMicrofluidic channelsSequential deliveryZero-order drug deliverypH-triggered delivery

More Related Videos

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.8K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.6K

Related Experiment Videos

Last Updated: Feb 16, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

14.2K
Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.8K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.6K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Drug Delivery Systems

Background:

  • Controlled drug delivery aims to improve therapeutic efficacy and reduce side effects.
  • Existing microfabricated systems often lack systematic investigation of release channels for precise control.
  • Achieving controlled, predictable drug release remains a significant challenge in pharmaceutical development.

Purpose of the Study:

  • To develop microchannel-based drug delivery devices with precisely controlled release rates.
  • To demonstrate the modulation of drug release by microchannel geometry.
  • To explore sequential and pH-responsive drug delivery using microfluidic systems.

Main Methods:

  • Design and fabrication of micro-reservoirs and microchannels with varied geometric parameters.
  • Drug release studies using model drugs to assess release kinetics.
  • Finite element modeling to predict drug delivery unit performance.
  • Demonstration of sequential release using biodegradable polymer plugs.
  • Investigation of pH-responsive delivery and cell viability tests.

Main Results:

  • Drug release rates were successfully modulated by altering microchannel dimensions (length, width, number, straightness).
  • Finite element modeling accurately predicted the performance of the microchannel drug delivery units.
  • Sequential drug delivery was achieved using biodegradable polymer plugs within microchannels.
  • pH-responsive drug delivery was demonstrated, with implications for targeted therapies.

Conclusions:

  • Microchannel geometry provides a powerful tool for precise control over drug release kinetics.
  • Microfluidic systems offer a versatile platform for developing advanced drug delivery devices.
  • Engineered microchannels enable predictable, customizable, and responsive drug delivery for enhanced therapeutic outcomes.