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Updated: Feb 16, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
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Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

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Potential microRNA-related Targets for Therapeutic Intervention with Ovarian Cancer Metastasis

Ulrich H Weidle1, Fabian Birzele2, Gwen Kollmorgen1

  • 1Roche Innovation Center Munich, Roche Diagnostics GmbH, Penzberg, Germany.

Cancer Genomics & Proteomics
|December 25, 2017
PubMed

Insights

MicroRNAs play a key role in ovarian cancer metastasis. This review highlights microRNAs that promote or suppress epithelial ovarian cancer (EOC) spread, offering insights for new therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Disseminated epithelial ovarian cancer (EOC) presents a significant challenge in clinical treatment.
  • Identifying novel therapeutic targets is crucial for improving patient outcomes.
  • MicroRNAs (miRNAs) are increasingly recognized for their role in cancer progression and metastasis.

Purpose of the Study:

  • To review the role of microRNAs in mediating metastasis of epithelial ovarian cancer (EOC).
  • To summarize metastasis-promoting and metastasis-suppressing miRNAs in EOC.
  • To discuss the therapeutic potential of miRNA-based strategies for metastatic EOC.

Main Methods:

  • Literature review focusing on preclinical (in vitro and in vivo) studies.
  • Analysis of clinical correlations of miRNA functions in metastasis.
  • Examination of current and future therapeutic interventions targeting miRNAs.

Main Results:

  • Several microRNAs are identified as significantly up-regulated, promoting EOC metastasis.
  • Other microRNAs are found to be down-regulated, acting as suppressors of EOC metastasis.
  • Preclinical data demonstrate the functional impact of these miRNAs on metastatic processes.

Conclusions:

  • MicroRNAs are critical regulators of epithelial ovarian cancer (EOC) metastasis.
  • Targeting specific microRNAs offers a promising avenue for novel therapeutic strategies.
  • Further research is needed to overcome challenges in miRNA-based therapeutics for metastatic EOC.
Keywords:
Antisense oligonucleotidesascites fluidepithelial mesenchymal transitionepithelial ovarian cancerextracellular matrixlocked nucleic acidsmesothelial cellsperitoneal disseminationreview

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