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Updated: May 26, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Prostate Cancer: De-regulated Circular RNAs With Efficacy in Preclinical In Vivo Models

Ulrich H Weidle1, Fabian Birzele2

  • 1Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany; weidle49@t-online.de fabian.birzele@roche.com.

Cancer Genomics & Proteomics
|February 24, 2025
PubMed

Insights

Circular RNAs (circRNAs) are key regulators in prostate cancer progression and treatment resistance. Identifying dysregulated circRNAs offers new therapeutic targets for improving prostate cancer treatment efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer treatment faces significant challenges due to therapy resistance, including castration-resistance and metastasis.
  • Circular RNAs (circRNAs) are increasingly recognized for their roles in cancer development and progression.

Purpose of the Study:

  • To identify dysregulated circRNAs impacting treatment efficacy in preclinical prostate cancer models.
  • To discover novel therapeutic targets and strategies for overcoming prostate cancer resistance.

Main Methods:

  • A comprehensive literature search was performed on PubMed.
  • Focused on preclinical *in vivo* models of prostate cancer related to treatment resistance.
  • Identified and cataloged deregulated circRNAs and their associated biological processes.

Main Results:

  • Identified 49 circRNAs implicated in various cancer-related processes.
  • These circRNAs are linked to treatment resistance, protein regulation, signaling pathways, and epigenetic modifications.
  • Specific circRNAs were associated with transmembrane and secreted proteins, transcription factors, and metabolism.

Conclusions:

  • Dysregulated circRNAs represent promising targets for prostate cancer therapy.
  • Down-regulated circRNAs may be candidates for reconstitution therapy.
  • Up-regulated circRNAs can potentially be targeted by small interfering RNA (siRNA), antisense oligonucleotides (ASO), or CRISPR-Cas approaches.
Keywords:
Circ RNA-protein interactioncastrate-resistant prostate cancer (CRPC)drug deliverymetastasismiR-spongingreviewsiRNA

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