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Deregulated circRNAs in Epithelial Ovarian Cancer With Activity in Preclinical In Vivo Models: Identification of

Ulrich H Weidle1, Fabian Birzele2

  • 1Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany; weidle49@t-online.de.

Cancer Genomics & Proteomics
|April 26, 2024
PubMed

Insights

This study identifies circular RNAs (circRNAs) that are up- or down-regulated in epithelial ovarian cancer (EOC) models. These circRNAs offer potential new therapeutic targets for overcoming chemotherapy resistance and metastasis in EOC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Epithelial ovarian cancer (EOC) presents a poor prognosis due to chemoresistance and metastasis.
  • Identifying novel therapeutic targets is crucial for improving EOC patient outcomes.

Purpose of the Study:

  • To systematically review and categorize circular RNAs (circRNAs) implicated in epithelial ovarian cancer (EOC) preclinical models.
  • To identify potential therapeutic targets and modalities for EOC treatment.

Main Methods:

  • Literature search for up- and down-regulated circRNAs in preclinical in vivo EOC models.
  • Categorization of identified circRNAs based on their biological functions and pathways.

Main Results:

  • Identified circRNAs associated with cisplatin and paclitaxel resistance.
  • Found circRNAs involved in transmembrane receptors, secreted factors, transcription factors, RNA processing, RAS pathway, and cell-cycle regulation.
  • Highlighted circRNAs regulating signaling pathways and proteins in various categories.

Conclusions:

  • Identified circRNAs represent promising targets for EOC therapy.
  • Potential therapeutic strategies include target validation, circRNA inhibition (ASO, siRNA, shRNA), or reconstitution of activity.
Keywords:
Inhibition and reconstitution of circ RNAreviewsmall hairpin RNA (shRNA)small interfering RNA (siRNA)target validationxenograft models

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