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Updated: Feb 16, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
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New therapeutic directions to treat underactive bladder
Toby C Chai1, Tambudzai Kudze1
1Department of Urology, Yale University School of Medicine, New Haven, CT, USA.
Investigative and Clinical Urology
|December 28, 2017
Summary
New therapies for underactive bladder (UAB), a condition of bladder hypocontractility, are being explored. Research focuses on drug therapy, regenerative medicine, neuromodulation, and devices to improve bladder emptying.
Area of Science:
- Urology
- Regenerative Medicine
- Pharmacology
Background:
- Underactive bladder (UAB) presents as symptoms of bladder hypocontractility.
- Detrusor underactivity (DUA) is the urodynamic diagnosis for decreased bladder contractility.
- Currently, no regulatory-approved treatments specifically enhance bladder contractility exist.
Purpose of the Study:
- To review potential novel therapeutic strategies for detrusor underactivity (DUA).
- To explore treatments aimed at augmenting the motor or sensory pathways of the micturition reflex.
- To discuss regenerative techniques targeting detrusor smooth muscle function.
Main Methods:
- Review of current and emerging therapeutic approaches for DUA.
- Discussion of drug therapy, stem cell and regenerative therapies.
- Exploration of neuromodulation and urethral flow assist devices.
Main Results:
- Several promising avenues for DUA treatment are under investigation.
- Regenerative medicine and targeted drug therapies show potential for increasing detrusor muscle function.
- Neuromodulation and devices may offer alternative methods for improving bladder emptying.
Conclusions:
- Novel therapies including drug, regenerative, and device-based approaches are being developed for DUA.
- Further clinical studies are needed to correlate DUA with UAB and validate new treatments.
- Enhancing bladder contractility and improving emptying efficiency are key goals for UAB management.
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