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Phenolic glycosides from Lavandual angustifolia
Nigary Yadikar1,2, Khayrulla Bobakulov3, H A Aisa1,4
1a The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry , Chinese Academy of Sciences , Urumqi 830011 , China.
Journal of Asian Natural Products Research
|December 28, 2017
Summary
Researchers identified four new phenolic glycosides from Lavandula angustifolia waste. Some compounds showed antioxidant activity, while one new compound increased melanin content in melanoma cells.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Lavender (Lavandula angustifolia) essential oil extraction generates waste rich in bioactive compounds.
- Phenolic glycosides are a class of natural products with diverse biological activities.
- Investigating compounds from plant waste can lead to novel discoveries and sustainable resource utilization.
Purpose of the Study:
- To isolate and characterize new phenolic glycosides from Lavandula angustifolia essential oil extraction waste.
- To evaluate the antioxidant potential of isolated compounds using DPPH free radical scavenging assay.
- To assess the effect of new compounds on melanin production in B16 melanoma cells.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation through comprehensive spectroscopic analyses (1D/2D NMR, HR-ESI-MS, UV, optical rotation).
- Chemical methods and literature data comparison for structural confirmation.
Main Results:
- Four new phenolic glycosides (1-4) and 12 known phenolic glycosides (5-16) were isolated and identified.
- Compounds 1, 8, and 13 exhibited DPPH free radical scavenging activity.
- Compound 2 demonstrated a dose-dependent increase in melanin content in B16 melanoma cells.
Conclusions:
- The study successfully identified novel phenolic glycosides from Lavandula angustifolia waste.
- Specific isolated compounds possess antioxidant properties and influence melanin synthesis.
- This research highlights the potential of utilizing plant waste for discovering bioactive molecules.
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