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Related Experiment Video

Updated: Feb 16, 2026

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Interneuron Cooperativity in Cortical Circuits.

Mahesh M Karnani^1,2, Jesse Jackson³

¹1 Francis Crick Institute, London, UK.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry

|December 29, 2017

Summary

This summary is machine-generated.

Neurons can act together in ensembles or individually. This study explores neuronal cooperativity, defining it and examining how individual and group actions of neocortical inhibitory interneurons are regulated.

Keywords:

cooperativity interneurons neocortex neuronal ensemble

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Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Neocortical neurons often exhibit coactivity within functional groups known as ensembles.
Individual neurons can also fire independently, posing questions about the regulation of transitions between individual and cooperative activity.

Purpose of the Study:

To explore the concept of neuronal cooperativity, drawing parallels with classical biochemistry.
To define neuronal cooperativity, review existing evidence, and propose experimental methods to investigate it, focusing on neocortical inhibitory interneurons.

Main Methods:

Application of the concept of neuronal cooperativity, inspired by biochemical models.
Review of recorded incidences and proposed mechanisms of neuronal cooperativity.
Description of experimental approaches to demonstrate and characterize neuronal cooperativity.

Main Results:

Proposes a working definition of neuronal cooperativity for neocortical inhibitory interneurons.
Suggests that neuronal team cooperativity is evident in vivo through both ensemble coactivity and the behavior of individual 'soloist' neurons.
Highlights the role of soloist neurons at the lower end of a sigmoidal cooperativity curve.

Conclusions:

Neuronal cooperativity provides a framework for understanding the regulation of individual versus ensemble neuronal activity.
Both coordinated ensemble firing and independent single-neuron firing are manifestations of neuronal cooperativity.
Further research is needed to fully elucidate the evidence for and implications of individual and collective neuronal actions.