Structure Activity Relationship of Venom Toxins Targeting Potassium Channels

Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.

This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.

Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.

The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.

This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.