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Encapsulated Optically Responsive Cell Systems: Toward Smart Implants in Biomedicine.
Christophe Boss1, Nicolas Bouche1, Umberto De Marchi2
1Device Engineering, Nestlé Institute of Health Sciences, EPFL Innovation Park, Lausanne, CH-1015, Switzerland.
Advanced Healthcare Materials
|December 29, 2017
Summary
Smart implantable biosensors combine genetically engineered cells with optical systems for continuous health monitoring. This technology offers new perspectives for chronic disease management and biomedical research.
Area of Science:
- Biomedical Engineering
- Cellular Biosensing
- Implantable Diagnostic Systems
Background:
- Chronic diseases necessitate continuous patient monitoring.
- Cell-based biosensors offer potential for implantable diagnostic systems.
- Cell encapsulation enables long-term in vivo functionality of cellular systems.
Purpose of the Study:
- To highlight recent advancements in genetically encoded sensors, cell encapsulation, and miniaturized optical systems.
- To demonstrate the integration of these components for novel biosensor development.
- To explore applications in biomedical research and in vivo health monitoring.
Main Methods:
- Genetic engineering of optically responsive cells.
- Development of advanced cell encapsulation techniques.
- Integration with miniaturized optoelectronic systems.
Main Results:
- Creation of smart implantable cell-based sensing systems.
- Demonstration of real-time imaging capabilities using genetically encoded fluorescent sensors.
- Establishment of a new generation of in vivo biosensors.
Conclusions:
- The integration of advanced technologies enables innovative smart in vivo cell-based systems.
- These systems offer novel perspectives for biomedical research, including studying cell signaling and drug efficacy.
- The technology holds promise for unique health monitoring applications, particularly for chronic diseases.
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