Meeting the multiscale challenge: representing physiology processes over ApiNATOMY circuits using bond graphs.

Area of Science:

• Computational Biology
• Physiology Modeling
• Systems Biology

Background:

• Representing complex physiological processes across multiple scales remains a challenge.
• Integrating diverse biophysical processes within biological structures requires robust modeling frameworks.

Purpose of the Study:

• To introduce and demonstrate the application of bond graph formalism within the ApiNATOMY framework.
• To model acid-base physiology scenarios, linking distinct process modalities.
• To provide a semantically and mathematically explicit basis for multiscale physiology representation.

Main Methods:

• Utilizing the bond graph formalism to explicitly represent biophysical processes.
• Embedding bond graphs onto ApiNATOMY compartments.
• Focusing on modeling scenarios from acid-base physiology.

Main Results:

• Demonstrated successful application of bond graphs for representing inter- and intra-compartmental biophysical processes.
• Linked distinct process modalities using bond graphs within an ApiNATOMY circuit.
• Established a coherent basis for representing multiscale physiology and compartmental topology.

Conclusions:

• Bond graph formalism integrated with ApiNATOMY offers a powerful approach for modeling multiscale physiological systems.
• This method enhances the semantic and mathematical explicitness of physiological process representation.
• The approach facilitates coherent integration and visualization of complex biological systems.