Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Correlation and Causation01:27

Correlation and Causation

43.0K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
43.0K
Complement System01:27

Complement System

11.0K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
11.0K
Complementation Tests00:49

Complementation Tests

6.3K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.3K
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

464
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
464
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

918
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
918
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

649
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
649

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utility of multimodal sampling and testing during advanced bronchoscopy for diagnosing atypical respiratory infections in a <i>Coccidioides</i>-endemic region.

Journal of thoracic disease·2023
Same author

Longitudinal trends of systemic lupus erythematous hospitalizations in the United States: a two-decade population-based study.

Clinical rheumatology·2022
Same author

Effectiveness of Angiotensin II for Catecholamine Refractory Septic or Distributive Shock on Mortality: A Propensity Score Weighted Analysis of Real-World Experience in the Medical ICU.

Critical care explorations·2022
Same author

Randomized, placebo controlled, double blinded pilot superiority phase 2 trial to evaluate the effect of curcumin in moderate to severe asthmatics.

BMC pulmonary medicine·2021
Same authorSame journal

SLE and Serum Complement: Causative, Concomitant or Coincidental?

The open rheumatology journal·2018
Same journal

Association Between <i>STAT4</i> rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.

The open rheumatology journal·2018
Same journal

Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN-γ, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients.

The open rheumatology journal·2018
Same journal

Tocilizumab in Large Vessel Vasculitis - Different Routes of Administration.

The open rheumatology journal·2018
Same journal

Plasma Saturated and Monounsaturated Fatty Acids in Behçet's Disease.

The open rheumatology journal·2018
Same journal

Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus.

The open rheumatology journal·2018
See all related articles

Related Experiment Video

Updated: Feb 16, 2026

Measuring the 50% Haemolytic Complement CH50 Activity of Serum
08:26

Measuring the 50% Haemolytic Complement CH50 Activity of Serum

Published on: March 29, 2010

39.0K

SLE and Serum Complement: Causative, Concomitant or Coincidental?

Vaneet Sandhu1, Michele Quan2

  • 1Division of Rheumatology, Loma Linda University Medical Center, Loma Linda, CA, USA.

The Open Rheumatology Journal
|January 2, 2018
PubMed
Summary
This summary is machine-generated.

Systemic Lupus Erythematosus (SLE) management involves monitoring complement levels, but low levels do not always indicate flares. Novel methods assessing cell-bound complement may offer better insights into SLE disease activity.

Keywords:
CB-CAPSComplementSLESLE flares'Systemic Lupus Erythematosus

More Related Videos

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.7K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Related Experiment Videos

Last Updated: Feb 16, 2026

Measuring the 50% Haemolytic Complement CH50 Activity of Serum
08:26

Measuring the 50% Haemolytic Complement CH50 Activity of Serum

Published on: March 29, 2010

39.0K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.7K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K

Area of Science:

  • Immunology
  • Rheumatology

Background:

  • Systemic Lupus Erythematosus (SLE) is an autoimmune disease where complement activation contributes to tissue damage.
  • Current monitoring of SLE disease activity relies on serum complement levels, a practice established in the 1950s.

Purpose of the Study:

  • To clarify the relationship between complement deficiency and SLE phenotypes.
  • To understand if complement deficiency is causative, concomitant, or coincidental in SLE.

Main Methods:

  • A literature review of PubMed was performed using keywords 'complement,' 'SLE,' and 'SLE flares' from 1972 to 2017.
  • Included English-only clinical studies and review articles focusing on complement level measurement and interpretation in SLE.

Main Results:

  • Complement activation is integral to SLE pathophysiology.
  • Decreased serum complement levels (C3 and C4) are not consistently linked to SLE disease flares.

Conclusions:

  • Continued monitoring of serum C3 and C4 is recommended for assessing SLE disease activity.
  • Novel assessment methods, such as measuring cell-bound complement activation products, may provide a more accurate reflection of SLE disease activity compared to traditional serum markers.