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What Have We Learned from Perfusion MRI in Multiple Sclerosis?

E Lapointe1,2, D K B Li3, A L Traboulsee4,2

  • 1From the Division of Neurology (E.L., A.L.T.) emmanuelle.lapointe@usherbrooke.ca.

AJNR. American Journal of Neuroradiology
|January 6, 2018
PubMed

Insights

Multiple sclerosis (MS) patients show altered brain perfusion on MR imaging. Acute lesions may hyperperfuse due to inflammation, while normal brain tissue may hypoperfuse, correlating with cognitive issues.

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Imaging

Background:

  • Cerebral perfusion alterations are observed in multiple sclerosis (MS) compared to healthy individuals.
  • Perfusion can be assessed using dynamic susceptibility contrast MR imaging or arterial spin-labeling.

Purpose of the Study:

  • To investigate cerebral perfusion changes in MS using MR imaging.
  • To explore the relationship between perfusion alterations and clinical symptoms like cognitive impairment and fatigue.

Main Methods:

  • Utilized MR imaging techniques, including dynamic susceptibility contrast and arterial spin-labeling.
  • Compared perfusion in MS patients (lesions and normal-appearing matter) with healthy controls.

Main Results:

  • Acute MS lesions show relative hyperperfusion compared to normal-appearing white matter, attributed to inflammation.
  • Normal-appearing white and gray matter in MS patients often exhibit hypoperfusion compared to controls.
  • Hypoperfusion in MS correlates with cognitive impairment and fatigue.

Conclusions:

  • Perfusion MR imaging may aid in early detection of inflammatory changes and new lesions in MS.
  • Perfusion changes could serve as a marker for cognitive dysfunction in MS.
  • Further research is needed to clarify the clinical relevance and pathogenesis of MS-related perfusion changes.

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