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What Have We Learned from Perfusion MRI in Multiple Sclerosis?

E Lapointe1,2, D K B Li3, A L Traboulsee4,2

  • 1From the Division of Neurology (E.L., A.L.T.) emmanuelle.lapointe@usherbrooke.ca.

AJNR. American Journal of Neuroradiology
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Multiple sclerosis (MS) patients show altered brain perfusion on MR imaging. Acute lesions may hyperperfuse due to inflammation, while normal brain tissue may hypoperfuse, correlating with cognitive issues.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Imaging

Background:

  • Cerebral perfusion alterations are observed in multiple sclerosis (MS) compared to healthy individuals.
  • Perfusion can be assessed using dynamic susceptibility contrast MR imaging or arterial spin-labeling.

Purpose of the Study:

  • To investigate cerebral perfusion changes in MS using MR imaging.
  • To explore the relationship between perfusion alterations and clinical symptoms like cognitive impairment and fatigue.

Main Methods:

  • Utilized MR imaging techniques, including dynamic susceptibility contrast and arterial spin-labeling.
  • Compared perfusion in MS patients (lesions and normal-appearing matter) with healthy controls.

Main Results:

  • Acute MS lesions show relative hyperperfusion compared to normal-appearing white matter, attributed to inflammation.
  • Normal-appearing white and gray matter in MS patients often exhibit hypoperfusion compared to controls.
  • Hypoperfusion in MS correlates with cognitive impairment and fatigue.

Conclusions:

  • Perfusion MR imaging may aid in early detection of inflammatory changes and new lesions in MS.
  • Perfusion changes could serve as a marker for cognitive dysfunction in MS.
  • Further research is needed to clarify the clinical relevance and pathogenesis of MS-related perfusion changes.