Urinary Nucleosides and Deoxynucleosides
Małgorzata Patejko1, Wiktoria Struck-Lewicka1, Danuta Siluk1
1Medical University of Gdańsk, Gdańsk, Poland.
Abstract:
Urinary nucleosides and deoxynucleosides are mainly known as metabolites of RNA turnover and oxidative damage of DNA. For several decades these metabolites have been examined for their potential use in disease states including cancer and oxidative stress. Subsequent improvements in analytical sensitivity and specificity have provided a reliable means to measure these unique molecules to better assess their relationship to physiologic and pathophysiologic conditions. In fact, some are currently used as antiviral and antitumor agents. In this review we provide insight into their molecular characteristics, highlight current separation techniques and detection methods, and explore potential clinical usefulness.
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