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Optimized tableting for extremely oxygen-sensitive probiotics using direct compression.

Rania Allouche1, Sébastien Dupont1, Alexandre Charriau1

  • 1Université de Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, F-21000, Dijon, France.

International Journal of Pharmaceutics
|January 9, 2018
PubMed
Summary
This summary is machine-generated.

Direct compression can successfully produce viable Faecalibacterium prausnitzii probiotic tablets. This method ensures the anaerobic bacteria survive processing and storage, maintaining therapeutic potential for intestinal health.

Keywords:
Direct compressionExcipientsF. prausnitziiPre-consolidationStorageTabletsViability

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Area of Science:

  • Microbiology
  • Pharmaceutical Technology
  • Gastroenterology

Background:

  • Faecalibacterium prausnitzii possesses anti-inflammatory properties beneficial for intestinal health.
  • Reduced abundance of F. prausnitzii is linked to chronic intestinal diseases.
  • Challenges in utilizing F. prausnitzii include oxygen sensitivity and ensuring gut survival.

Purpose of the Study:

  • To evaluate the impact of direct compression on F. prausnitzii viability.
  • To assess the influence of compression pressure and storage conditions on probiotic survival.
  • To identify suitable excipients for enhancing probiotic tablet stability.

Main Methods:

  • Investigated direct compression effects on F. prausnitzii using Microcrystalline Cellulose (MCC), Hydroxypropyl Methylcellulose (HPMC), and Hydroxypropyl Methylcellulose Phthalate (HPMCP).
  • Assessed cell viability under varying compression pressures and storage durations (28 days at 25°C, 11% RH, anaerobic conditions).
  • Employed a pre-consolidation strategy to mitigate temperature increase and shearing forces during compression.

Main Results:

  • Probiotic cell viability decreased linearly with increasing compression pressure.
  • MCC and HPMC demonstrated superior performance as carrier excipients.
  • Tablets maintained a survival rate above 10^8 CFU after storage under optimized conditions (201 MPa).
  • Pre-consolidation significantly improved survival rates by reducing thermal and mechanical stress.

Conclusions:

  • Direct compression is a viable method for manufacturing tablets with oxygen-sensitive probiotics like F. prausnitzii.
  • Optimized compression and storage conditions ensure probiotic stability and therapeutic efficacy.
  • The study provides a strategy for producing stable probiotic formulations for intestinal applications.