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Optimized tableting for extremely oxygen-sensitive probiotics using direct compression

Rania Allouche1, Sébastien Dupont1, Alexandre Charriau1

  • 1Université de Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, F-21000, Dijon, France.

International Journal of Pharmaceutics
|January 9, 2018
PubMed

Insights

Direct compression can successfully produce viable Faecalibacterium prausnitzii probiotic tablets. This method ensures the anaerobic bacteria survive processing and storage, maintaining therapeutic potential for intestinal health.

Area of Science:

  • Microbiology
  • Pharmaceutical Technology
  • Gastroenterology

Background:

  • Faecalibacterium prausnitzii possesses anti-inflammatory properties beneficial for intestinal health.
  • Reduced abundance of F. prausnitzii is linked to chronic intestinal diseases.
  • Challenges in utilizing F. prausnitzii include oxygen sensitivity and ensuring gut survival.

Purpose of the Study:

  • To evaluate the impact of direct compression on F. prausnitzii viability.
  • To assess the influence of compression pressure and storage conditions on probiotic survival.
  • To identify suitable excipients for enhancing probiotic tablet stability.

Main Methods:

  • Investigated direct compression effects on F. prausnitzii using Microcrystalline Cellulose (MCC), Hydroxypropyl Methylcellulose (HPMC), and Hydroxypropyl Methylcellulose Phthalate (HPMCP).
  • Assessed cell viability under varying compression pressures and storage durations (28 days at 25°C, 11% RH, anaerobic conditions).
  • Employed a pre-consolidation strategy to mitigate temperature increase and shearing forces during compression.

Main Results:

  • Probiotic cell viability decreased linearly with increasing compression pressure.
  • MCC and HPMC demonstrated superior performance as carrier excipients.
  • Tablets maintained a survival rate above 10^8 CFU after storage under optimized conditions (201 MPa).
  • Pre-consolidation significantly improved survival rates by reducing thermal and mechanical stress.

Conclusions:

  • Direct compression is a viable method for manufacturing tablets with oxygen-sensitive probiotics like F. prausnitzii.
  • Optimized compression and storage conditions ensure probiotic stability and therapeutic efficacy.
  • The study provides a strategy for producing stable probiotic formulations for intestinal applications.
Keywords:
Direct compressionExcipientsF. prausnitziiPre-consolidationStorageTabletsViability

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