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Updated: Feb 16, 2026

Analysis of Global RNA Synthesis at the Single Cell Level following Hypoxia
Published on: May 13, 2014
The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
L D Lukyanova1, Yu I Kirova2, E L Germanova2
1Research Institute of General Pathology and Pathophysiology, Moscow, Russia. ldlukyanova@gmail.com.
Abstract:
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.
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